$119.00
Tesofensine is a novel, centrally acting triple monoamine reuptake inhibitor (MRI) that simultaneously suppresses the synaptic clearance of norepinephrine, serotonin, and dopamine. Originally investigated for its robust central nervous system activity, this small-molecule bicyclic compound has become a cornerstone reference standard in academic and biomedical laboratories exploring energy balance, neuropharmacology, and metabolic regulation.
CAS Number: 195875-84-4 (Free base) / 402856-42-2 (Citrate)
Molecular Weight: 332.28 g/mol
Purity: >99% (HPLC Verified)
Solubility: Soluble in DMSO and aqueous buffers
Storage: Store at -20°C, protected from moisture and direct light
Unlike traditional single-target agents, this compound modifies synaptic transmission across three distinct monoaminergic pathways. Preclinical and cellular models evaluate these pathways to map complex neuroendocrine responses:
Monoamine Transporter Inhibition: Selectively binds to dopamine transporters (DAT), norepinephrine transporters (NET), and serotonin transporters (SERT) to elevate synaptic neurotransmitter availability.
Hypothalamic Satiety Signaling: Modulates neuronal populations within the lateral hypothalamus, influencing energy expenditure and feeding behavioral models.
Metabolic Rate Dynamics: Investigates non-shivering thermogenesis and energy expenditure pathways separate from baseline appetite suppression.
When designing experimental parameters, researchers must account for structural classifications. Although commonly mislabeled in informal literature as a tesofensine peptide, it is structurally a non-peptide azabicyclooctane derivative. Establishing precise experimental models often relies on preparing a standardized tesofensine dosage—frequently working with concentrated references such as a tesofensine 500mcg metric to measure lower-tier receptor occupancy and threshold kinetics.
For academic institutions and authorized screening facilities evaluating procurement options, identifying a reliable source offering tesofensine for sale requires rigorous verification of high-performance liquid chromatography (HPLC) purity reports. Securing consistent batches ensures absolute reproducibility across advanced neurochemical and metabolic assays.
Basepeptides.us delivers premium-grade research compounds synthesized to exacting scientific criteria. Each batch undergoes comprehensive analytical validation to guarantee absolute structural integrity and consistent molar concentrations for institutional research.
This product is sold strictly for laboratory research use only. Not for human consumption. By purchasing, you acknowledge that you are at least 18 years of age and that this product will be used exclusively for legitimate research purposes. Peptides require reconstitution, instructions are not provided, nor are directions on dosing and usage. Products are intended strictly for research purposes by skilled professionals.
