$90.00
P-21 (also documented as P021) is a synthetic, adamantane-modified tetrapeptide derived from the active region of human ciliary neurotrophic factor (CNTF). Engineered to overcome the typical limitations of full-length neurotrophic proteins—such as rapid enzymatic degradation and poor blood-brain barrier permeability peptide functions as a potent experimental analog for investigating central nervous system pathways and synaptic plasticity.
Sequence Structure: Adamantane-conjugated tetrapeptide derivative ($\text{Ac-DGGLAG-NH}_2$)
Molecular Weight: 985.11 g/mol
CAS Number: 1246751-68-7
Purity: $\ge$99% (Verified via High-Performance Liquid Chromatography)
Form: Lyophilized reference powder
Storage: Store desiccated at -20°C
Preclinical and in vitro investigations focus on how p-21 peptide interacts with endogenous growth factor systems. Unlike short-acting nootropics that merely modulate neurotransmitter release, this compound is studied for structural and neurogenic mechanisms:
BDNF Upregulation: Stimulates brain-derived neurotrophic factor expression, promoting downstream activation of the TrkB/MAP-kinase signaling cascades.
LIF Signaling Inhibition: Competitively inhibits leukemia inhibitory factor pathways, removing suppressive barriers against neural progenitor cell proliferation in the hippocampus.
Tau Phosphorylation Modulation: Interacts with GSK-3β pathways to evaluate the reduction of abnormal tau accumulation and amyloid-beta aggregation in neurodegeneration models.
When structuring institutional budgets or designing laboratory protocols, researchers often look to secure a reliable source to buy p-21 peptide for comparative assay work. Because structural integrity dictates experimental reproducibility, laboratories evaluating where to buy p-21 peptide prioritize vendors providing complete high-performance liquid chromatography and mass spectrometry validation packets.
Investigators examining synthesis standards for a legitimate p-21 buy option must verify that materials arrive as lyophilized reference standards designated strictly for laboratory research rather than human administration.
Basepeptides.us delivers high-purity research materials manufactured to exacting specifications. Every batch of P-21 undergoes rigorous third-party analytical testing to guarantee absolute molecular fidelity, stability, and experimental consistency across advanced neurobiological studies.
This product is sold strictly for laboratory research use only. Not for human consumption. By purchasing, you acknowledge that you are at least 18 years of age and that this product will be used exclusively for legitimate research purposes. Peptides require reconstitution, instructions are not provided, nor are directions on dosing and usage. Products are intended strictly for research purposes by skilled professionals.
