5-Amino-1MQ

Metabolic Enzyme Inhibition Research: 5-Amino-1MQ

At BasePeptides.us, we deliver high-purity research compounds to support academic laboratories and bio-analytical facilities. Although frequently discussed in peptide libraries, 5-Amino-1MQ (5-amino-1-methylquinolinium) is actually a cell-permeable, small-molecule quinolinium derivative that functions as a selective inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). By targeting metabolic pathways at the cellular level, this compound provides a valuable standard for studying energy regulation and intracellular cofactors.

Technical & Product Specifications

• Molecular Weight: 159.21 g/mol

• CAS Number: 42464-96-0

• Purity: $\ge$99% (Verified via HPLC and Mass Spectrometry)

• Form: Lyophilized reference powder

• Storage: Store at -20°C in a desiccated environment, protected from light

Pharmacological Mechanism & Enzymatic Targets

NNMT is a key metabolic enzyme that catalyzes the methylation of nicotinamide using S-adenosylmethionine (SAM) as a methyl donor, producing 1-methylnicotinamide. This enzymatic action diverts nicotinamide away from the NAD+ salvage pathway and consumes methyl groups that would otherwise support epigenetic regulation.

In vitro and preclinical research models utilize 5-amino-1mq peptide categories (technically small-molecule analogues) to examine several primary scientific areas:

• NAD+ Biosynthesis: Evaluates how competitive inhibition of NNMT affects intracellular NAD+ salvage pathways and sirtuin activity.

• Adipose Tissue Metabolism: Investigates lipid accumulation markers, adipocyte differentiation, and cellular energy expenditure in diet-induced metabolic models.

• Methyl Donor Flux: Measures shifts in the SAM/SAH cellular ratio to understand downstream epigenetic methylation patterns.

Laboratory Handling & Experimental Sourcing

When designing in vitro assays or cell culture protocols, researchers carefully establish parameters such as an exact 5-amino-1mq dosage to monitor enzyme inhibition thresholds and cell viability metrics. Preclinical studies tracking systemic exposure often evaluate a standardized 5-amino-1mq dosage per day metric to assess sustained metabolic pathway modulation over multi-day experimental runs.

For institutional laboratories seeking consistent material quality, sourcing a verified grade of 5-Amino-1MQ requires comprehensive high-performance liquid chromatography analysis and batch-specific certificates of authenticity. Basepeptides.us ensures that every batch maintains strict purity standards for advanced biochemical research.