$225.00
PNC-27 is an innovative anti-cancer peptide consisting of a p53-derived amino acid sequence (residues 12-26) linked to a transmembrane-penetrating or membrane-residency peptide (MRP) domain. Developed as a targeted biochemical tool, it is designed to investigate selective tumor cell cytotoxicity and membrane-receptor dynamics in laboratory models. Researchers examining novel oncological pathways utilize this reference compound to explore non-apoptotic cell death mechanisms across diverse cell lines.
Sequence Composition: p53 (12-26) residues conjugated to a transmembrane-penetrating domain
Target Receptor: Human double minute 2 (HDM-2 / MDM2) protein expressed on malignant cell membranes
Purity Standards: $\ge$98% via High-Performance Liquid Chromatography (HPLC)
Form: Lyophilized reference powder
Storage Conditions: Store desiccated at -20°C
Unlike conventional chemotherapeutic agents that induce traditional caspase-mediated apoptosis, pnc-27 peptide operates through a unique membranolytic pathway. In malignant cells, the human double minute 2 (HDM-2) protein is frequently expressed abnormally within the plasma membrane rather than being confined strictly to the cell nucleus.
Preclinical studies indicate that PNC-27 selectively targets and binds to this membrane-bound HDM-2 protein. This interaction results in the aggregation of oligomeric ring-shaped structures, forming transmembrane pores that lead directly to rapid tumor cell necrosis while leaving untransformed, healthy cell lines unaffected. Furthermore, investigations show that the peptide can interact with mitochondrial membranes, causing secondary organelle disruption in target cancer models without triggering off-target toxicity in normal primary fibroblasts.
When planning experimental assays, academic institutions and specialized biotech facilities looking to buy pnc-27 must prioritize analytical rigor, requiring complete mass spectrometry and HPLC purity verification. Securing a reliable pnc-27 peptide for sale ensures that batch-to-batch consistency is maintained for sensitive in vitro cytotoxicity assays and cell membrane localization studies.
As interest grows within experimental oncology, laboratories evaluating options for pnc-27 for sale rely on certified distributors that provide thorough documentation regarding peptide sequence integrity and net peptide content.
Basepeptides.us delivers premium research-grade compounds synthesized to the highest scientific standards. Each batch of PNC-27 undergoes rigorous analytical testing to ensure structural validation and optimal experimental reproducibility for advanced biochemical research.
This product is sold strictly for laboratory research use only. Not for human consumption. By purchasing, you acknowledge that you are at least 18 years of age and that this product will be used exclusively for legitimate research purposes. Peptides require reconstitution, instructions are not provided, nor are directions on dosing and usage. Products are intended strictly for research purposes by skilled professionals.
